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来源:Scientific Reports 发布光阴:2019/5/10 14:36:26
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DNA数据存储的端到端主动化展现

论文标题:Demonstration of End-to-End Automation of DNA Data Storage

期刊:Scientific Reports

作者:Christopher N. Takahashi, Bichlien H. Nguyen, Karin Strauss, Luis Ceze

发表光阴:2019/03/21

数字辨认码:10.1038/s41598-019-41228-8

原文链接:http://t.cn/EScQ2XI

合成DNA已经成为一种用于计算机数据编码的新型载体,其储存密度要比现代尖端技术高出几个数目级。然而,即使借助主动合成和测序设备,很多中央步骤仍然必要专业的试验室技术职员来履行。近期发表在Scientific Reports的研究Demonstration of End-to-End Automation of DNA Data Storage展现了一种新开拓的主动化端到端DNA存储设备,研究职员盼望由此探究在这种独特应用程序的束缚下要想实现主动化会面对哪些挑衅。

应用这个新设备可将数据编码为DNA序列,然后应用定制的DNA合成仪将其写入DNA寡核苷酸,之后将这些寡核苷酸会合起来以液体情势储存,并应用纳米孔测序仪和一种新颖的、准备工作最少的计划停止读取。研究职员在文章中展现了主动化的5字节写入、储存和读取周期,该周期采纳了模块化设计,跟着新技术的赓续推出可实现进一步的扩大。

图1:写入、存储和读取流程示用意

摘要:However, even with the help of automated synthesis and sequencing devices, many intermediate steps still require expert laboratory technicians to execute.

We have developed an automated end-to-end DNA data storage device to explore the challenges of automation within the constraints of this unique application. Our device encodes data into a DNA sequence, which is then written to a DNA oligonucleotide using a custom DNA synthesizer, pooled for liquid storage, and read using a nanopore sequencer and a novel, minimal preparation protocol. We demonstrate an automated 5-byte write, store, and read cycle with a modular design enabling expansion as new technology becomes available.

阅读论文全文请访问:http://t.cn/EScQ2XI

期刊介绍:Scientific Reports (https://www.nature.com/srep/) is an online, open access journal from the publishers of Nature. We publish scientifically valid primary research from all areas of the natural and clinical sciences.

The 2017 journal metrics for Scientific Reports are as follows:

•2-year impact factor: 4.122

•5-year impact factor: 4.609

•Immediacy index: 0.576

•Eigenfactor® score: 0.71896

•Article Influence Score: 1.356

•2-year Median: 2

(来源:华人科技资讯网)

 
 
 
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